MHRA Alert – Paracetamol in pregnancy remains safe; no autism link

Paracetamol and pregnancy: reassurance for patients and clinicians

The MHRA has issued a reminder that paracetamol remains safe to use during pregnancy and there is no evidence that it causes autism in children. This update addresses recent concerns and reinforces current clinical guidance.

Key points

• Paracetamol is the first-choice pain reliever for pregnant women
• No causal link exists between paracetamol use in pregnancy and autism
• Patients should be reassured and encouraged to use paracetamol as recommended for pain and fever management during pregnancy
• Healthcare professionals should continue to counsel pregnant patients confidently on safe analgesia options

Clinical action

Remind pregnant patients that paracetamol is a safe and appropriate choice for managing pain and fever during pregnancy. Address any anxieties about autism risk with confidence, backed by current evidence. Continue to recommend paracetamol as first-line analgesia in line with standard guidance.

For the full MHRA safety update, visit the MHRA website.